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- Daily Refill - May 30 2025 – Five brand-new studies you haven’t scrolled past (yet)
Daily Refill - May 30 2025 – Five brand-new studies you haven’t scrolled past (yet)
Mushrooms, Money Stress & a Mind-Bladder Hack—Can Science Save Your Weekend?
Matthew Tilmann
May 30, 2025
Feel like Friday comes with equal parts burnout and endless to-do tabs?
Today’s sprint through the latest research shows why a single dose of psilocybin might reboot anhedonia, how a vibrating headset + mindfulness quiets “latchkey” leaks, and why Gen Z just declared peace of mind > paycheck.
Grab the mug; let’s refill.
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1️⃣ One-Dose Psilocybin Trial Targets “Joy Shutdown”
Summary UCHealth researchers launched a phase II trial testing a single psilocybin dose, plus therapy, for patients whose depression no longer responds to meds. Primary endpoint: reviving pleasure response within 28 days.
Why it matters Anhedonia is stubborn; if psychedelics move the dial, they could open a whole new lane of fast-acting care.
Try it Not DIY—yet. But track micro-pleasures (sunlight, song) this weekend; logging them primes the brain for reward sensitivity.
2️⃣ Financial Anxiety Hits All-Time High—76 % Feel Alone
Summary A May 2025 HLTH poll shows 71 % of Gen Z and 69 % of Gen X report money anxiety; 76 % feel they’re coping solo.
Why it matters Financial stress now outpaces politics and health as America’s top worry. Chronic worry raises blood pressure and sleep debt.
Try it Block 30 minutes to update (or start) your YNAB or spreadsheet; studies say even seeing a plan trims cortisol.
3️⃣ Mindfulness + Brain Stimulation Calms “Latchkey Incontinence”
Summary Patients practicing breath-focused mindfulness while wearing a mild scalp-stimulation device cut cue-triggered bladder leaks and urgency.
Why it matters Shows mindfulness can tame not just mood but body reflexes—promising for other stress-linked conditions.
Try it Pair your next “gotta go” feeling with three slow inhales, one long exhale; note if urgency eases.
4️⃣ A Decade of Data: Exercise Outruns Depression
Summary Tracking thousands, researchers found regular moderate activity halved depression incidence versus sedentary peers—even after controlling for genetics.
Why it matters It’s as potent as meds, minus side effects.
Try it Set a “movement bookmark”: 10 squats or a brisk 5-minute walk between afternoon meetings.
5️⃣ Mindfulness Training Tunes Attention Networks in 4 Weeks
Summary Participants completing 10 minutes/day of guided mindfulness shifted EEG signatures linked to sustained attention and emotional regulation.
Why it matters Adds neural proof to “feel better, focus better” claims—no headset needed.
Try it This newsletter ends; set a 2-minute timer, notice the breath, label distractions “thinking,” return. Repeat tomorrow.
Quote of the Day
“Progress happens when the why gets personal.”
60-Second Challenge
Grab Snipd (yesterday’s sponsor!) and clip one 30-second podcast gem, then paste it into a gratitude text—solidifies learning and lifts mood.
Weekend deep dive? Parent-preneur frameworks land every Sunday via Mitten Dad Minute, and my full gear stack lives at Apparent Solopreneur.
Stay curious!
— Matt
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